Cholesterol profile in women with premature menopause after risk reducing salpingo-oophorectomy
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چکیده
منابع مشابه
Bone density loss after risk reducing salpingo-oophorectomy
Women undergoing risk-reducing salpingo-oophorectomy through the Prince of Wales Hospital Hereditary Cancer Clinic are offered enrolment in a prospective study of bone mineral density (BMD), markers of bone metabolism and cardio-vascular risk factors. Participants are invited to enroll a friend who has ovaries in situ and are aged within five years of the participant as a control population. Lu...
متن کاملRisk-reducing salpingo-oophorectomy for BRCA mutation carriers.
It has been twenty years since the region of the BRCA1mutationwas identified on chromosome 17q. There are now over 3000 risk reducing salpingo-oophorectomy (RRSO) cases reported and an estimated 150 cases describing unsuspected cancers of the ovaries and tubes or in situ lesions. Connor et al. in their current study add to the literature on RRSO outcomes [1]. They report on 345 cases of RRSO in...
متن کاملWhat have we learned from risk-reducing salpingo-oophorectomy?
In this issue of the Journal, Rebbeck et al. (1) have provided us with a meticulously executed, up-to-date meta-analysis that quantifies the reductions in the risks of breast and ovarian/fallopian tube cancer that follow risk-reducing salpingo-oophorectomy (RRSO) in BRCA1 and BRCA2 (BRCA1/2) mutation carriers. Their conclusion — " The summary risk reduction estimates presented here indicate tha...
متن کاملWhat Happens After Menopause? (WHAM): protocol for a prospective, multicentre, age-matched cohort trial of risk-reducing bilateral salpingo-oophorectomy in high-risk premenopausal women
INTRODUCTION Women at high inherited risk of ovarian cancer are advised to undergo risk-reducing bilateral salpingo-oophorectomy (RRBSO) at age 40-45 years or when their families are complete. Most women are premenopausal at this age, so RRBSO will induce surgical menopause. Despite the clear benefits of RRBSO for cancer risk reduction, much less is known about the impact on non-cancer outcomes...
متن کاملElevated Bone Turnover Markers after Risk-Reducing Salpingo-Oophorectomy in Women at Increased Risk for Breast and Ovarian Cancer
BACKGROUND Risk-reducing salpingo-oophorectomy (RRSO) reduces ovarian cancer risk in BRCA1/2 mutation carriers. Premenopausal RRSO is hypothesized to increase fracture risk more than natural menopause. Elevated bone turnover markers (BTMs) might predict fracture risk. We investigated BTM levels after RRSO and aimed to identify clinical characteristics associated with elevated BTMs. METHODS Os...
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ژورنال
عنوان ژورنال: Familial Cancer
سال: 2018
ISSN: 1389-9600,1573-7292
DOI: 10.1007/s10689-018-0091-5